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Wilkes-Barre ( WILKS-bair or -⁠bair-ee) is a city in the U.S. state of Pennsylvania and the county seat of Luzerne County. Located at the center of the Wyoming Valley in Northeastern Pennsylvania, it had a population of 44,328 in the 2020 census. It is the second-largest city, after Scranton, in the Scranton–Wilkes-Barre–Hazleton, PA Metropolitan Statistical Area, which had a population of 563,631 as of the 2010 census and is the fourth-largest metropolitan area in Pennsylvania after the Delaware Valley, Greater Pittsburgh, and the Lehigh Valley with an urban population of 401,884.

Scranton/Wilkes-Barre is the cultural and economic center of a region called Northeastern Pennsylvania, which is home to over 1.3 million residents. Wilkes-Barre and the surrounding Wyoming Valley are framed by the Pocono Mountains to the east, the Endless Mountains to the north and west, and the Lehigh Valley to the south. The Susquehanna River flows through the center of the valley and defines the northwestern border of the city.

Wilkes-Barre was founded in 1769 and formally incorporated as a borough in 1806, and as a city in 1869. The city grew rapidly in the 19th century after the discovery of nearby coal reserves and the arrival of hundreds of thousands of immigrants who provided a labor force for the local mines. The coal mining fueled industrialization in the city, which reached the height of its prosperity in the first half of the 20th century. Its population peaked at more than 86,000 in 1930. Following World War II, the city's economy declined due to the collapse of industry. The Knox Mine disaster accelerated this trend after large portions of the area's coal mines were flooded and could not be reopened. Today, the city has around half of its peak population of the 1930s, making it the largest city in Luzerne County and the 13th-largest city in Pennsylvania. The contiguous network of 5 cities and more than 40 boroughs all built in a straight line in Northeastern Pennsylvania's urban area act culturally and logistically as one continuous city, so while the city of Wilkes-Barre itself is a smaller town, the larger unofficial city of Scranton/Wilkes-Barre contains nearly half a million residents in roughly 200 square miles.

Wilkes-Barre is located 73.7 miles (118.6 km) northwest of Allentown and 122.4 miles (197.0 km) northwest of New York City.